Dansinger M, et al. - In this study involving a very large cohort of 14,121 women and 13,969 men, researchers evaluated the links between changes in high-density lipoprotein and body mass index (ΔBMI). They measured age and sex-adjusted Δapo A1 concentrations within 10 HDL subfractions and identified the significance at .01 < P ≤ .05 (*), .001 < P ≤ .01 (†), .0001 < P ≤ .001 (‡), and P ≤ .0001 (§). They noted a significant impact of weight change on HDL-cholesterol concentrations throughout the obesity spectrum. In healthy-weight patients who became overweight, overweight patients who became class I or class II obese, class I obese patients who became class II obese, and class II obese patients who became class III, a remarkable decline in HDL-cholesterol was evident. In contrast, increase in HDL-cholesterol was detected in class III obese patients who became class II or class I, class II obese patients who became class I or overweight, class I patients who became overweight or healthy weight, overweight patients who became healthy weight, and healthy weight patients who became underweight. Nearly twice a greater impact of ΔBMI's on Δα-1 was observed vs its effect on HDL-cholesterol.