Husain S, et al. - Researchers investigated how an oral probiotic preparation administered from early pregnancy influence the vaginal microbiota via performing the randomized, double-blind, placebo-controlled trial at 4 maternity units in the UK. They randomly allocated the participants to receive oral capsules of probiotic containing Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 each at 2.5 × 109 colony-forming units (CFUs) or placebo once daily from recruitment until the end of pregnancy. At 18–20 weeks' gestation, they determined rates of bacterial vaginosis (BV, defined as Nugent score ≥7) compared by logistic regression adjusted for possible confounders. No change in vaginal microbiota was seen when oral probiotics were taken from early pregnancy.