Afat IM, et al. - Experts conducted a prospective, randomized, double-blind, controlled study to assess the impacts of leukocyte- and platelet-rich fibrin (L-PRF) alone and combined with hyaluronic acid (HA) sponge on early healing of soft tissue after mandibular third molar (M3) surgery. Findings suggested the efficacy of L-PRF alone and when combined with HA to improve soft tissue healing. This treatment entity could be used to prevent postoperative alveolar osteitis and infection after M3 surgery. For both the L-PRF group and the L-PRF+HA group, the mean healing scores for the mucosa on the 7th, 14th, and 21st days were significantly better than those for the control group.