Lascelles K, et al. - Via a qualitative study of semi-structured interviews with 14 patients who had received ketamine treatment for depression, experts examined patients’ reports of the effects of treatment on their suicidal ideation (SI), the term of impacts and possible mechanisms. In 12 out of 14 participants, SI declined after ketamine treatment for periods of a few hours after a single treatment to up to three years with ongoing treatment. Decrease of SI was variable in terms of extent and span, and re-emergence of suicidal thoughts often happened when treatment was stopped. Participants’ accounts suggested that declined SI was related to enhanced mood and decreased anxiety, as were clarity of thought, focus and concentration, and ability to function. Participants reported experiencing some or all of these impacts in different orders of occurrence. Usually, ketamine treatment was encountered as efficient in decreasing SI, however, term of impact differed considerably. Patients’ perspectives inferred comparability in the mechanisms of decrease in SI, but some variations in their manifestation, especially in association with chronology. Moreover, decreased anxiety and improvement in ability to think and function were significant mechanisms alongside, or in some cases independently of, betterment in mood.