Elfandi S, Ooto S, Miyata M, et al. - In this retrospective, comparative case series analysis, researchers compared the 12-month effectiveness of intravitreous aflibercept (IVA) injection between eyes with pachychoroid neovasculopathy and neovascular age-related macular degeneration (AMD). Twenty-seven eyes had pachychoroid neovasculopathy, while 63 had neovascular AMD. IVA injections were given to all patients three times a month at first, then bi-monthly after that. In both pachychoroid neovasculopathy and neovascular AMD, the mean best-corrected visual acuity improved 12 months after initial therapy. Twelve months after initial treatment, eyes with pachychoroid neovasculopathy showed decreased mean central retinal thickness and subfoveal choroidal thickness and presence of polyps and improved integrity of the external limiting membrane and ellipsoid zone band. In eyes with pachychoroid neovasculopathy and neovascular AMD, regular IVA injection improves anatomical and functional outcomes.