Creamer MR, Dutra LM, Sharapova SR, et al. - Researchers sought to determine whether the declining trend in U.S. youth cigarette smoking changed after e-cigarettes were introduced and whether youth e-cigarette users were likely to smoke cigarettes based on psychosocial and demographic smoking predictors. An interrupted time-series analysis was utilized for cross-sectional data from the 2004 to 2018 National Youth Tobacco Surveys to evaluate changes in cigarette and e-cigarette use over time. Findings revealed that the decline in current cigarette smoking slowed in 2014 and the decline in ever cigarette smoking accelerated after 2012. A slow decline in current cigarette smoking, a stall in combined cigarette and e-cigarette use, and an accelerated decrease in cigarette smoking have followed the introduction of e-cigarettes. Traditional psychosocial risk factors for cigarette smoking indicate that the traditional risk profile of cigarette smokers does not suit e-cigarette users.