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Effects of dietary intervention on vitamin B12 status and cognitive level of 18-month-old toddlers in high-poverty areas: A cluster-randomized controlled trial

BMC Pediatrics Sep 21, 2019

Sheng X, et al. - Researchers examined the vitamin B12 status of toddlers living in high-poverty areas of China. In addition, they determined how the vitamin B12 status and cognitive level of these toddlers are affected by different complementary foods. In a cluster-randomized controlled trial implemented in 60 administrative villages (clusters) of Xichou County, this study was nested was . In this trial, randomization of infants aged 6 months old to receive 50 g/d of pork (meat group), an equi-caloric fortified cereal supplement (fortified cereal group) or local cereal supplement (local cereal group) for one year, was done. The children exhibited median serum concentrations of vitamin B12 and total homocysteine (tHcy) of 360.0 pg/mL and 8.2 μmol/L, respectively. The fortified cereal group showed the highest vitamin B12 level (509.5 pg/mL), followed by the meat group (338.0 pg/mL) and the local cereal group (241.0 pg/mL). Due to low dietary vitamin B12 intake, vitamin B12 deficiency in toddlers was common in poor rural areas of China. They observed a positive correlation of vitamin B12 concentration with the cognitive score and the fine motor score of the Bayley Scales of Infant Development, 3rd Edition screening test. Higher cognitive scores were observed among children in the meat group vs the local cereal group.
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