Kim SJ, et al. - Via performing a nationwide population-based study involving 116,677 individuals who were prescribed with the same antihypertensive drugs for at least 1 year, researchers determined whether single-pill combinations (SPCs) of antihypertensives can improve medication adherence by using representative national data in a real-world setting. Participants were randomized into groups of angiotensin II receptor blocker (ARB)-only, calcium channel blocker (CCB)-only, multiple-pill combinations (MPCs), and SPCs of ARB/CCB. In combination therapy, adjusted medication possession ratio (MPR) was higher than that of monotherapy, and MPR of SPC was higher than MPR of MPC. In those aged 65–74 years and ≥ 75 years, adherence of SPC and MPC was 92.3% vs 88.1% and 89.3% vs 84.8%, respectively. Adherence of SPC and MPC was 90.9% vs 85.3% in 7-8 pills and 91.2% vs 82.5% in ≥ 9. A progressing elevation in the adherence difference between SPC and MPC at 5-6 pills and at age 50–64 years was observed. Upon analysis of elderly status, the adherence difference rose at 3-4 pills in the elderly and at 5-6 in the non-elderly. These differences increased further with increasing age and total medications. Hence, higher adherence to SPC regimens than MPC was identified. Furthermore, this tendency was more clear with increasing age and the total number of medications.