Tulloch-Reid MK et al. - In the current study it was shown thatincreased total cholesterol, but not inflammatory markers (CRP and IL-6), was associated with low-grade prostate cancer in Caribbean men.

Methods
40–80 year old Jamaican male patients (229 cases and 252 controls) were studied.
Cases had incident histologically-confirmed prostate cancer and controls had normal digital rectal examination and prostate-specific antigen (PSA) or free:total PSA > 0.15 obtained from the same clinic.
Total and HDL-cholesterol, IL-6, and CRP were measured from non-fasting samples.

Results
The mean total cholesterol (cases, 4.71 ± 1.07; controls, 4.64 ± 1.07 mmol/L), median CRP (cases, 2.11; controls, 2.09 µg/ml), and median IL-6 (cases, 3.34; controls, 3.24 pg/ml) did not differ by PCA status.
Higher total cholesterol was associated with an increased risk of low-grade prostate cancer.
Total cholesterol was unrelated to overall prostate cancer or high-grade disease.
There was no significant association between HDL-cholesterol or CRP and IL-6 with prostate cancer.