Hall E, et al. - Researchers assessed BRCA mutation carriers who elected to undergo a bilateral salpingo-oophorectomy (BSO) in order to determine the impact of BSO on non-cancer outcomes, including quality of life (QOL), menopausal symptoms, and sexual functioning. Studying 140 BRCA mutation carriers, they noted a significant worsening of menopausal symptoms and a decline in sexual functioning 3.5 years after oophorectomy, particularly among those who underwent surgery prior to natural menopause. Some but not all these effects were reduced using HRT. Overall, no decline in the QOL was observed among women who were premenopausal at surgery.