Hu J, Yang C, Yang G, et al. - Treatment with atorvastatin 80 mg prior to- and 40 mg/day post- PCI (percutaneous coronary intervention) in acute myocardial infarction (AMI) patients can effectively decrease serum inflammatory factors. Independent associations of procalcitonin and high-sensitivity C-reactive protein (hs-CRP) with in-hospital major adverse cardiovascular events (MACEs) were found.

• A total of 112 patients with AMI (23 women and 89 men) were included; they were randomly assigned to atorvastatin 20 mg/day postoperatively (20-mg group), 40 mg/day postoperatively (40-mg group) and 80 mg preoperatively+40 mg/day postoperatively (80/40-mg group).

• Relative to 20-mg and 40-mg groups, the 80/40-mg group had significantly decreased serum procalcitonin levels at 1 and 3 days post-PCI as well as decreased hs-CRP levels at 3 days.

• Following were independently linked with MACEs during hospitalization: serum procalcitonin (OR, 4.593), hs-CRP (OR, 1.149), highly sensitive cardiac troponin T (OR, 1.255) and Gensini score (OR, 1.022).