Yousafzai MT, Karim S, Qureshi S, et al. - This study was undertaken to investigate the effectiveness and impact of the typhoid conjugate vaccine Typbar-TCV against Salmonella enterica serotype Typhi (S Typhi) among children in an outbreak setting of extensively drug-resistant (XDR) S Typhi in Pakistan. Researchers conducted a cohort study including a total of 23,407 children from the census registry and surveillance system between Feb 21, 2018, and Dec 31, 2019. This study’s findings demonstrate that Typbar-TCV is effective in protecting children against S Typhi infection in an outbreak setting, and was able, with moderate deployment, to curtail a major XDR S Typhi outbreak in a densely populated setting. Furthermore, the vaccine indicates effectiveness against S Typhi irrespective of antimicrobial resistance.