Rostami M, et al. - Whether a prenatal screening program can be effective for optimizing 25-hydroxyvitamin D (25[OH]D) levels and for preventing pregnancy complications was investigated in this study conducted at health centers of Masjed-Soleyman and Shushtar cities. Also, researchers intended to identify a safe regimen. For this purpose, they compared several regimens in a subgroup of pregnant women who were vitamin D-deficient. In the screening site vs nonscreening site, a greater (53% vs 2%) percentage of women were able to meet the sufficiency level (> 20 ng/mL) after supplementation. The maximum achievement of sufficient levels at delivery was reported in cases where a vitamin D₃ injection was administered in addition to monthly 50,000 IU maintenance therapy. Overall, findings suggested a prenatal vitamin D screening and treatment program is effective in detecting deficient women, improving 25(OH)D levels, and decreasing pregnancy adverse outcomes. In the screening site, preeclampsia, gestational diabetes mellitus, and preterm delivery were decreased by 60%, 50%, and 40%, respectively.