Yarandi RB, Amiri M, Tehrani FR, et al. - Since several meta-analyses on gestational diabetes mellitus (GDM) and its related treatments, including oral antidiabetic agents and insulin, have been published, and the reliability of their findings is a concern, owing to a lack of methodological quality assessment of these studies, researchers sought to evaluate the methodological quality of available meta-analyses and provide a summary estimation of the effectiveness of treatments modalities. A Measurement Tool to Assess Systematic Reviews was applied to assess the methodological quality of eligible meta-analyses. In total, 27 and 17 studies were involved for qualitative and quantitative syntheses, respectively; of these, just four studies were classified as high quality. When compared with insulin and glyburide, metformin had the highest probability of being the best treatment for the majority of adverse neonatal outcomes, while glyburide was the best treatment for reducing the risk of adverse maternal outcomes. Despite the fact that the majority of the available meta-analyses were of low quality, the results of the available literature demonstrated that metformin is the best alternative to insulin therapy for women with GDM due to maternal and perinatal outcomes comparable to insulin. The findings should be updated further by including future, more qualified studies.