Gonzalez MAP, et al. - This study is performed to examine the effectiveness and safety of outpatient parenteral antibiotic therapy (OPAT) in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in patients admitted to home hospitalisation units (HHU). Avoiding hospital stays, readmissions and complications, patients with AECOPD who require parenteral antimicrobial therapy can be managed successfully and safely in HHU.