Amano S, et al. - In this investigation, researchers studied the impact of topical prostaglandin (PG) eyedrops on the biomechanics and shape of the cornea. The study sample consisted of consecutive patients with primary open-angle glaucoma who were treated with the same anti-glaucoma PG (114 eyes, 57 patients) or β-blocker (36 eyes, 18 patients) eyedrops in 1 eye alone for more than 3 months at Inouye Eye Hospital or Miyata Eye Hospital. Using a Corvis ST device (Oculus, Wetzlar, Germany), the biomechanical properties of the cornea were measured. A Casia 1 or 2 (Tomey Corp., Nagoya, Japan) was used to measure corneal tomography. The eyes treated with PG had a significantly smaller one-time applanation, the highest concavity radius, and greater amplitude of deformation than the contralateral eyes. The PG-treated eyes also had a significantly smaller one-time applanation and two velocities applanation but a greater peak distance than the β-blocker-treated eyes. No significant differences in any of the Casia parameters between the PG-treated eyes and the contralateral eyes were found. The findings of this research indicate that topical PG changes the cornea biochemically, but does not change its shape.