Korgavkar K, et al. - The researchers used validated photonumeric scales to examine the effect of topical fluorouracil, 5%, cream on photoaging. They found no improvement in photoaging with a standard course of topical fluorouracil, 5%, cream, a finding that could be attributable to a true lack of effect in photodamage or limitations of the photonumeric scales in capturing the effect. They recommended considering the development of photonumeric scales that include manifestations of photoaging other than rhytids, like lentigines, hyperpigmentation, and telangiectasias.