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Effect of timing of surgical resection of primary hepatocellular carcinoma on survival outcomes in elderly patients and prediction of clinical models

BMC Gastroenterology May 28, 2021

He Y, Liang T, Mo S, et al. - This study attempted to evaluate the effect of surgical timing on the prognosis of elderly hepatocellular carcinoma patients undergoing surgical resection and constructed a Nomogram model to predict the overall survival of patients. Between 2012 and 2018, researchers conducted a retrospective analysis including a total of 232 elderly hepatocellular carcinoma patients who had undergone hepatectomy. Using the cut-off times of 18 days, 30 days, and 60 days, the effect of surgical timing on the prognosis of elderly patients with liver cancer was examined. They used Cox to examine the independent influencing factors of overall survival in patients, and a prognostic model was constructed. This study’s findings demonstrate that the operative time has no significant effect on delayed operation in elderly patients with hepatocellular carcinoma, and a moderate delay may benefit some patients. In elderly patients with hepatectomy, the constructed Nomogram model is a good predictor of overall survival.

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