Baqar S, Kong YW, Chen AX, et al. - Given a paradoxical association of lower sodium intake with higher mortality in type 2 diabetes (T2D), researchers here examined the contribution of sympathetic nervous system (SNS) activation and endothelial dysfunction to these observations. For this purpose, they determined how salt supplementation affects these systems in people with T2D with habitual low sodium via performing a randomized, double-blinded, placebo-controlled crossover trial. As per their hypothesis, salt supplementation would lead to reduction in SNS activity and an improvement in endothelial function compared with placebo. Twenty-two people with T2D with habitual low sodium intake (24-hour urine sodium < 150 mmol/24h) were underwent salt supplementation (100 mmol NaCl/24h) or were provided placebo for 3 weeks. Outcomes revealed increased SNS activity in relation to salt supplementation among these people, with no change in endothelial function or blood pressure but improved baroreflex function, a predictor of cardiac mortality. Improved endothelial function was observed in salt-resistant individuals with salt supplementation.