Santiago AEQ, et al. - In this prospective, randomized, comparative, and double-blinded study, researchers investigated the effect of a single preoperative dose of pregabalin for analgesia after nephrectomy. The study was conducted in 40 kidney transplant donors, between 18 and 60 years, American Society of Anesthesia physical status I or II. Patients were administered epidural anesthesia with 15 mL of 0.5% ropivacaine single shot and general anesthesia with 3 µg/kg of fentanyl, propofol, atracurium, and sevoflurane, and 50% of oxygen without nitrous oxide. Either 300 mg of pregabalin or placebo, 1 hour prior to surgery was administered to patients. To supplement postoperative analgesia, tramadol was administered. Pregabalin in a single preoperative dose of 300 mg was noted to lower the pain intensity 24 hours after lumbotomy. The pregabalin and placebo group showed no differences in sensitivity of the thenar and peri-incisional region after 6 and 24 hours and in the number of patients requiring supplementation. The concentrations of IL-6, IL-8, and IL-10 and side effects (nausea, vomiting, dizziness, and pruritus) were also not different between the group.