Paget LDA, Reurink G, de Vos RJ, et al. - Treatment of ankle osteoarthritis using platelet-rich plasma (PRP) injections is not supported, because findings revealed that intra-articular PRP injections failed to significantly improve ankle symptoms and function over 26 weeks, vs placebo injections, in patients with ankle osteoarthritis.

• A multicenter, block-randomized, double-blinded, placebo-controlled clinical trial of 100 patients with ankle osteoarthritis who were randomized to receive 2 ultrasonography-guided intra-articular injections of either PRP (n = 48) or placebo (saline; n = 52).

• A mean change in the American Orthopedic Foot and Ankle Society score (range, 0-100; higher scores indicate less pain and better function) of 10 vs 11 points, over 26 weeks, was achieved with PRP injections vs placebo injections with saline.

• The between-group difference was not statistically significant (−1).