Trombetti A, et al. - Herein, the authors examined the link between a long-term, structured, moderate-intensity physical activity program with a lower risk for frailty. Additionally, they determined if frailty status altered the impact of physical activity on the reduction in major mobility disability (MMD) risk. No connection was revealed between such a program with a reduced risk for frailty over 2 years among sedentary, community-dwelling older adults. Data did not illustrate any variation in the beneficial effect of physical activity on the incidence of MMD between frail and nonfrail candidates.