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Effect of obstructive sleep apnoea and its treatment with continuous positive airway pressure on the prevalence of cardiovascular events in patients with acute coronary syndrome (ISAACC study): A randomised controlled trial

The Lancet Respiratory Medicine Apr 08, 2020

Sánchez-de-la-Torre M, Sánchez-de-la-Torre A, Bertran S, et al. - By performing this multicentre, open-label, parallel-group, randomised controlled trial, researchers assessed the impact of obstructive sleep apnoea (OSA) as well as its treatment with continuous positive airway pressure (CPAP) on the clinical evolution of patients with acute coronary syndrome (ACS). This study enrolled patients with ACS at 15 hospitals in Spain. All eligible patients had respiratory polygraphy during the first 24–72 h post-admission. Random assignment (1:1) of OSA patients to CPAP treatment plus usual care (CPAP group) or usual care alone (UC group) was done. A reference group including patients with ACS but without OSA was also included. A median follow-up of 3·35 years was performed. According to the findings, there was no link between the presence of OSA and an increased prevalence of cardiovascular events in non-sleepy patients with ACS, and no significant decrease in this prevalence was observed after treatment with CPAP.

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