Zeraatkar D, Johnston BC, Bartoszko J, et al. – A total of 12 randomized trials contrasting diets lower in red meat with diets higher in red meat that varied by a gradient of ≥ 1 serving per week for ≥ 6 months were analyzed by researchers to investigate the impact of lower vs higher red meat consumption on the incidence of cardiometabolic and cancer outcomes in adults. Although low-certainty, a single trial that included nearly 49,000 women offered the most reliable evidence that diets lower in red meat may contribute little to no impact on all-cause mortality, cardiovascular mortality, and cardiovascular disease. Furthermore, the trial offered low- to very-low-certainty evidence that diets lower in red meat may have little or no effect on total cancer mortality and the incidence of cancer, including colorectal and breast. Overall, according to the low- to very-low-certainty evidence uncovered in this systematic review, diets limited in red meat may have little or no effect on major cardiometabolic outcomes and cancer mortality and incidence.