Hernandez AV, et al. - Researchers evaluated the effectiveness of low-sodium salt substitutes (LSSS) as a potential intervention to reduce cardiovascular (CV) diseases by analyzing 21 randomized controlled trials (15 in hypertensive [n=2,016], 2 in normotensive [n=163], and 4 in mixed populations [n=5,224]) that compared detected hypertension, systolic blood pressure (SBP), diastolic blood pressure (DBP), overall mortality, stroke and other CV risk factors in those receiving LSSS vs regular salt. These studies were identified from five engines and ClinicalTrials.gov, which were searched from inception to May 2018. LSSS formulations were heterogeneous. Similar effects were noted across hypertensive, normotensive, and mixed populations. Significantly reduced SBP and DBP levels were noted with LSSS vs control, while no effect was evident for detected hypertension, overall mortality, and intermediate outcomes.