Rajapakse CS, Johncola AJ, Batzdorf AS, et al. - A randomized placebo‐controlled trial was designed to evaluate the impact of low-intensity vibration on bone strength, microstructure, and adiposity in pre‐osteoporotic postmenopausal women. Researchers applied this technology to a cohort of postmenopausal women with varying bone mineral density (BMD) T‐scores at the total hip (-0.524 ± 0.843) and spine (-0.795 ± 1.03) to analyze the response to intervention after one year of daily treatment with ten minutes of vibration therapy in a randomized double‐blinded trial. Primary outcomes included variations in bone stiffness at the distal tibia and marrow adiposity of the vertebrae, based on 3 Tesla high‐resolution MRI and spectroscopic imaging, respectively. Distal tibial trabecular microstructural parameters and vertebral deformity determined by MRI, volumetric and areal bone densities derived using peripheral quantitative computed tomography of the tibia, and dual‐energy x‐ray absorptiometry (DXA)‐based BMD of the hip and spine were considered as secondary outcome variables. This study’s findings demonstrate that vibration therapy is protective against loss in mechanical strength, and further, that the intervention minimizes the shift from the osteoblastic to the adipocytic lineage of mesenchymal stem cells.