Hirano T, et al. - Researchers conducted a pilot study of prospective, nonrandomized, multicenter clinical trial to determine the impact of foveal leaking microaneurysms (MAs) on the required number of intravitreal ranibiz­umab (IVR) injections in the treatment of center-involving diabetic macular edema (DME) when treated with focal/grid laser. For this investigation, they enrolled 21 eyes with DME for which pro re nata IVR injections were combined with short-pulse focal/grid laser. Significant improvements in the central subfield macular thickness (CMT) and an increase in best-corrected visual acuity (BCVA) of 4.0 ± 8.5 letters in 12 months were observed. The data presented in this work showed a combination therapy of short-pulse focal/grid laser and reduced IVR injections did not appear to be inferior to previous IVR monotherapy reports.