Manco–Johnson MJ, et al. – From the open–label, randomized, multinational SPINART study, 3–year bleeding, joint, health–related quality–of–life (HRQoL), and other outcomes had been described. Prophylaxis versus on–demand therapy (OD) in adults with severe hemophilia A and arthropathy led to decreased bleeding, pain, and healthcare resource utilization (HRU), better joint health, activity, satisfaction, and HRQoL, over 3 years. However, there was no reduction in structural arthropathy progression.