Jiang M, Ji J, Li X, et al. - Researchers assessed the impact of oxycodone on the physiologic alterations related to extubation during emergence from general anesthesia. Participants were 100 patients who had received assorted laparoscopic surgeries under general anesthesia. These were randomized to the Control group (saline injection, 50 cases) and Study group (intravenous injection of 0.08 mg/kg oxycodone immediately following completion of the surgical procedure, 50 cases). In the Control group, significantly higher blood pressure and heart rate as well as blood levels of epinephrine, norepinephrine, and cortisol were detected, vs the Study group, at the time of extubation as well as 1, 5, and 10 min post-extubation. Restlessness was felt by a significantly higher number of patients in the Control group prior to as well as following extubation, vs that in the Study group. Overall, changes of hemodynamics and blood hormones linked with extubation, during emergence from general anesthesia, were shown to be attenuated by intravenous oxycodone.