Senthil S, Burugupally K, Rout U, et al. - In a prospective interventional case series, researchers sought to assess the impact of preoperative intravenous (IV) dexmedetomidine on intraocular pressure (IOP) in adult patients undergoing glaucoma surgery under local anesthesia. Twelve patients [4 women and 8 men; mean age (± SD) 60.6 ± 10.4 years] with uncontrolled IOP (IOP > 24 mmHg in both the eyes) with the systemic status of American Society of Anesthesiologists (ASA) classification I-II, received IV dexmedetomidine 0.6 µg/kg 30 minutes preoperatively. In the limited sample of (ASA I-II) patients examined, preoperative dexmedetomidine showed a significant decrease in IOP (33%) within 15 minutes of IV administration in patients with 2-hour reverse glaucoma, with a strong safety profile. None of the participants encountered any adverse effects related to treatment.