Karalapillai D, Weinberg L, Peyton P, et al. - Researchers sought to ascertain the ideal tidal volume in patients who undergo mechanical ventilation during surgery via comparing postoperative pulmonary complications in correlation with intraoperative low tidal volume vs conventional tidal volume among patients undergoing major surgery. They performed single-center, assessor-blinded, randomized clinical trial of 1,236 patients (older than 40 years) undergoing major noncardiothoracic, nonintracranial surgery under general anesthesia lasting more than 2 hours in a tertiary hospital in Melbourne, Australia, from February 2015 to February 2019. Those randomized to a strategy of mechanical ventilation with low tidal volume had pulmonary complications rate of 38% within the first 7 postoperative days vs 39% among those randomized to a strategy with conventional tidal volume, a difference that was not statistically significant. This suggests that no significant reduction in postoperative pulmonary complications within the first 7 postoperative days occur among adults undergoing major surgery in correlation with an intraoperative mechanical ventilation strategy with low tidal volume.