Goldman MP, et al. – Researchers conducted the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial to evaluate the effects of intensive glucose control (IGC) on risk of lower extremity amputation (LEA) in type 2 diabetics. Study participants with type 2 diabetes were randomized to IGC (HbA1c target < 6.0%) or standard glycemic control (SGC; HbA1c target 7.0%-7.9%). The investigators found that, in type 2 diabetics, IGC was associated with a reduction in the risk of LEA. They noted an enduring protective effect against LEA after 3.7 years of IGC. In addition, findings revealed that improved glycemic control was a strong predictor for reduced risk for subsequent LEA. Study results thus indicate that strict glycemic control—even over a shorter duration of time—may decrease the risk of limb loss.