Daghlas I, et al. - Given that migraine has been implicated as a risk factor for coronary artery disease (CAD) and atrial fibrillation (AF) in observational studies; however, it remains unclear if migraine is causal in this link, therefore, researchers used two-sample Mendelian randomization to determine the potential causality between genetically instrumented liability to migraine and cardiovascular disease consequences. The 35 independent, genome-wide significant genetic variants recognized in the largest published genome-wide association study of migraine (Ncases = 59,674/Ncontrols = 316,078) were included as exposure. In this study, genome-wide association studies of CAD (76,014/264,785), myocardial infarction (43,676/128,199), angina (10,618/326,065) and AF (60,620/970,216) were used as the outcome datasets. Findings revealed a potentially protective influence of genetically instrumented liability to migraine on CAD risk. In analyses by migraine subtype, they found that CAD risk was influenced by liability to migraine without aura but not by migraine with aura.