Vincent LT, Grant J, Ebner B, et al. - Comparing in-hospital results between men and women admitted with Takotsubo syndrome (TTS), nearly 2.5-fold elevated in-hospital mortality risk was observed in men with TTS. Attenuation in morbidity and mortality could be achieved via early identification of cases with high-risk co-morbidities and close monitoring for arrhythmias, renal injury, or cardiogenic shock.

• Although postmenopausal women are largely affected by TTS, but this condition carries increased mortality risk in men.

• The National Inpatient Sample database (2011 to 2018) was used to include 48,300 hospitalizations with the primary diagnosis of TTS.

• Nationwide TTS death rates were 1.1% overall and may be improving, however, were higher in males vs females (2.2% vs 1.0%).

• Elevated all-cause mortality (adjusted odds ratios 2.41), greater length of stay, and discharge complexity were evident in men.

• There was an increased co-morbidity burden related to increased cardiogenic shock or mortality, including atrial fibrillation, thrombocytopenia, chronic kidney disease, and chronic obstructive pulmonary disease, among men.

• More frequent occurrence of acute kidney injury, ventricular arrhythmias, cardiac arrest, and respiratory failure was evident in males.