Jackson KE, Wang L, Casey JD, et al. - Researchers examined the influence of fluid composition during early resuscitation in the emergency department (ED) vs after intensive care unit (ICU) admission on sepsis outcomes via performing a secondary analysis of the Isotonic Solutions and Major Adverse Renal Events Trial (SMART) dataset examining medical ICU patients with a diagnosis of sepsis (n = 1,641). Enrollment of a total of 367 patients with sepsis during the ICU only period and 1,274 during the ED & ICU period was done. Outcomes suggest greater effect of balanced crystalloids vs saline on mortality among patients with sepsis, when fluid choice was controlled starting in the ED compared with starting in the ICU.