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Effect of diurnal variations in the carbohydrate and fat composition of meals on postprandial glycemic response in healthy adults: A novel insight for the second-meal phenomenon

American Journal of Clinical Nutrition Jul 11, 2018

Ando T, et al. - Researchers performed this secondary analysis of a study whose primary endpoint was energy metabolism (e.g., energy expenditure and substrate oxidation) to investigate if the glycemic response is raised when a meal with a higher carbohydrate content follows a meal with a lower carbohydrate content. In this crossover study, they used a continuous glucose monitoring system to assess blood glucose (BG) responses to 3 types of meals with different macronutrient contents (regular meals, meals with a high-carbohydrate breakfast, and meals with a high-fat breakfast). Findings revealed that, along with alterations in prioritization of carbohydrate utilization, switching from high-fat to high-carbohydrate meals resulted in larger postprandial BG excursions.

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