Korobelnik JF, et al. - An estimation was executed of the efficiency of dietary supplementation containing lutein, zeaxanthin, ω-3 polyunsaturated fatty acids, and vitamins. The intent was to increase the density of macular pigment in the first-generation offspring of parents with neovascular age-related macular degeneration (AMD). Despite plasma levels exhibiting continuous exposure to lutein and zeaxanthin, macular pigment optical density (MPOD) determined via modified Heidelberg Retina Angiograph (HRA) and the MPD-Visucam did not alter, after 6 months of lutein and zeaxanthin dietary supplementation, among the study cohort in the Lutein Influence on Macula of Persons Issued From AMD Parents [LIMPIA] trial. To comprehend the mechanism of absorption and metabolism of these nutrients in the macula, the best way to measure MPOD, and the clinical advantage, additional research was warranted.