Korobelnik JF, et al. - This study was initiated in order to compute the efficiency of dietary supplementation containing lutein, zeaxanthin, ω-3 polyunsaturated fatty acids, and vitamins. The intent was to increase the density of macular pigment in the first-generation offspring of parents with neovascular age-related macular degeneration (AMD). Regardless of the plasma levels illustrating a continuous exposure to lutein and zeaxanthin, macular pigment optical density (MPOD) estimated via modified Heidelberg Retina Angiograph (HRA) and the MPD-Visucam did not exhibit any modification after 6 months of lutein and zeaxanthin dietary supplementation, among the first-generation offspring of parents with neovascular AMD. In order to comprehend the mechanism of absorption and metabolism of such nutrients in the macula, the best strategy to estimate MPOD, and its clinical benefit for patients, prospective trials were required.