Zhang M, et al. - Via analyzing data from the Boston University Online Gout Study, an internet-based case-crossover study carried out from February 2003 to January 2012, researchers ascertained the association between omega-3 polyunsaturated fatty acid (n-3 PUFA) consumption (dietary or supplemental) and risk of gout flares. For the classification of the acute arthritis of primary gout, out of the 724 individuals, 85% met the 1977 American College of Rheumatology preliminary criteria. In the 48 hours before a gout flare or flare-free period, 22% of the individuals reported some form of n-3 PUFA consumption. For all three supplements combined and for the intake of at least 2 n-3 PUFA–rich fish servings, the adjusted odds ratios were 1.01 and 0.74, respectively. Therefore, when adjusted for total purine consumption, dietary n-3 PUFA–rich fish consumption was correlated with a lower risk of recurrent gout flares, whereas n-3 PUFA supplementation alone, as administered in a self-directed manner, was not. The investigators cautioned, however, that the consumption of specific sources and adequate doses of n-3 PUFA for gout flare prevention need additional study in a sufficiently powered clinical trial.