Salinero-Fort MA, Gómez-Campelo P, Cárdenas-Valladolid J, et al. - Researchers conducted the study for analyzing the impact of depression on all-cause mortality in patients with type 2 diabetes mellitus (T2DM) followed up during 8 years in primary care in Spain. In 3,923 people with T2DM, depression was diagnosed using the MINI 5.0.0 questionnaire, a physician's diagnosis, or two months of antidepressant therapy. Baseline depression was diagnosed in 22.1% of candidates. Age > 75 years, insulin use, lower limb amputation, heart failure, and male gender were the strongest predictors. Depression was linked to a higher risk of death in a Spanish cohort of older T2DM patients. More efforts are required to reduce the impact of depression on mortality in people with T2DM and to implement measures that allow for early diagnosis and effective treatment.