Nudelman MJR, et al. - Using MEDLINE, CINAHL, CENTRAL, EMBASE, and ClinicalTrials.gov databases, researchers contrasted the impact of delayed cord clamping on cord blood gas values in vaginally delivered, healthy, term singletons. The sample consisted of 234 newborns with early cord clamping and 218 newborns with delayed cord clamping. The observational studies demonstrated that 45–90 seconds delayed cord clamping was linked to mean reductions in umbilical arterial pH (0.02–0.03), HCO₃ (0.3–0.8 mmol/L) and increments in base deficit (0.3–1.3 mmol/L) vs early cord clamping. The authors discovered that delayed cord clamping up to 120 seconds has either no or only a small effect on cord blood acid-base balance; overall, the magnitude of these changes in vaginally delivered, healthy, term singletons is not clinically significant.