Humeidan ML, Reyes JPC, Mavarez-Martinez A, et al. - Among older adults, researchers conducted this prospective, single-blinded randomized clinical trial to ascertain if cognitive prehabilitation lessens the incidence of postoperative delirium. This trial was carried out at at the Ohio State University Wexner Medical Center in Columbus from March 2015 to August 2019. Eligible for trial inclusion were patients 60 years of age and older having major, noncardiac, nonneurological surgery under general anesthesia with an expected hospital stay of at least 72 hours. Of the 699 patients invited to participate in the trial, 251 were ultimately included in the analysis. Electronic, tablet-based preoperative cognitive exercise targeting memory, speed, attention, flexibility, and problem-solving functions was the intervention used in this study. Data reported that the delirium rate among control participants was 23.0%; with intention-to-treat analysis, the delirium rate in the intervention group was 14.4%. In patients who were at least minimally compliant, the intervention lowered the risk of delirium. Further study is needed for the ideal activities, timing, and effective dosage for cognitive exercise-based interventions to reduce the risk and burden of postoperative delirium.