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Effect of cognitive bias modification on early relapse among adults undergoing inpatient alcohol withdrawal treatment: A randomized clinical trial

JAMA Feb 07, 2021

Manning V, Garfield JBB, Staiger PK, et al. - Researchers examined if computerized cognitive bias modification (CBM) training during inpatient alcohol withdrawal treatment is linked with the odds of relapse in the first 2 weeks following discharge. They conducted a randomized clinical trial including 300 patients with alcohol use disorder receiving inpatient withdrawal treatment; 147 were randomized to receive CBM and 153 to receive sham treatment. Findings revealed correlation of receiving CBM with a significantly raised proportion of patients who maintained abstinence during the follow-up period (54.4% vs 42.5% with sham training) in intention-to-treat analysis and by 17% (63.8% vs 46.8%) in per-protocol analysis. These findings suggest that during alcohol withdrawal, cognitive bias modification is helpful in avoiding relapse during the high-risk early period after discharge from treatment. They recommend its implementation as an adjunctive intervention in this setting, as it is safe and easy to implement, requiring only a computer and joystick and needing no training.

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