Wang A, Tian X, Zuo Y, et al. - The risk of hemorrhagic stroke was positively linked to stable high serum uric acid (SUA), but not with total or ischemic stroke risk.

• In total, 51,441 candidates (mean age 52.69 ± 11.71 years) without a history of myocardial infarction or stroke were recruited.

• Based on SUA level fluctuations between 2006 and 2010, participants were categorized into four groups: stable low, increasing, decreasing, and stable high.

• One thousand six hundred eleven stroke (1,410 ischemic stroke, 199 hemorrhagic stroke, and 47 subarachnoid hemorrhage) were identified during 7.03-year follow up.

• When compared with participants with stable low SUA, those with stable high SUA had a greater risk of hemorrhagic stroke, with a hazard ratio (HR) of 1.93.

• Moreover, compared with cumulative low SUA exposure, cumulative high SUA exposure increased the risk of hemorrhagic stroke, with an HR of 2.99.

• However, there was no substantial indication that increases in SUA were linked to the risk of total and ischemic stroke, with HRs of 0.98 and 0.88, respectively.