Andraweera PH, et al. - Among 5,336 nulliparous women from the SCreening fOr Pregnancy Endpoints (SCOPE) study, researchers examined the influence of birth weight on the risk of pregnancy complications, including preeclampsia (PE), gestational hypertension (GH), small for gestational age (SGA) pregnancy, spontaneous preterm birth, and gestational diabetes mellitus (GDM), and evaluated the impact of early pregnancy BMI on this relationship. Findings showed that women born with birth weight < 2,500 g and who subsequently developed overweight or were diagnosed with obesity had an increased risk of GH, PE, and GDM vs women born with birth weight ≥ 2,500 g and remained lean. Investigators suggested that those who were born small may have received "programming" in response to unfavorable intrauterine conditions. The physiological demands of pregnancy might act as a “second hit,” leading to complications in the pregnancy in such women.