• Profile
Close

Effect of bicarbonate-buffered dialysate on ventricular arrhythmias in hemodialysis patients

American Journal of Nephrology Jan 07, 2019

Krahn RE, et al. - In 47 patients with end-stage renal disease (ESRD) on chronic hemodialysis (HD), researchers determined how frequency of ventricular arrhythmia was influenced by metabolic alkalosis induced by HD with an acetate-containing bicarbonate-buffered dialysate. They used 48-h Holter monitoring in 3 phases: intra-HD, post-HD day 1, and post-HD day 2. At pre-HD, post-HD, 20-h post-HD, and 44-h post-HD, they measured serum levels of bicarbonate, calcium, and potassium along with hemodynamics. They performed correlations to investigate direct or indirect associations of the HD-induced change in serum bicarbonate level (metabolic alkalosis) with ambient ventricular arrhythmia (premature ventricular contractions per hour). Findings revealed an association of high-bicarbonate dialysate prescription with metabolic alkalosis following the HD procedure. No direct association of a mild metabolic alkalosis induced by HD with an acetate-containing bicarbonate-buffered dialysate solution, with ambient ventricular arrhythmia on Holter monitoring was observed, and nor this was found to be related to changes in hemodynamics or changes in serum total calcium or potassium levels. Findings offer guidance for the safe use of high bicarbonate dialysate/prescription in patients with ESRD on HD.
Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay