Joris PJ, et al. - Researchers conducted a well-controlled trial investigating the effects of α-linolenic acid (ALA, C18:3n-3) on vascular function and metabolic risk markers during the fasting and postprandial phase in untreated (pre-)hypertensive individuals. Either 10 g of refined cold-pressed flaxseed oil, providing 4.7 g ALA (n = 29), or 10 g of high-oleic sunflower (control) oil (n = 30) was administered for 12 weeks to overweight and obese adults (40 men and 19 women; aged 60 ± 8 years) with a high-normal blood pressure or mild (stage I) hypertension. Outcomes revealed decreased fasting free fatty acid and TNF-α plasma concentrations in correlation to high intake of ALA, about 3–5 times the recommended daily intake, for 12 weeks. Other metabolic risk markers and vascular function during the fasting and postprandial phase did not show any change among the participants.