Duckworth AD, et al. - Researchers conducted this fracture and bisphosphonates trial to assess the impacts of early bisphosphonate therapy on fracture healing and functional outcome after fracture of the distal radius. For this trial, 421 bisphosphonate-naive subjects were recruited (aged ≥50 years) with a radiographically confirmed fracture of the distal radius and randomly allocated them 1:1 to receive alendronic acid 70 mg once weekly (n = 215) or placebo (n = 206) within 14 days of the fracture. According to findings, early administration of alendronic acid does not adversely impact fracture union or clinical outcome among patients aged 50 years and older with a distal radius fracture. These findings suggest that, if clinically indicated, bisphosphonate therapy can be safely started early after a fracture.