Hargrove N, El Tobgy N, Zhou O, et al. - By performing this systematic review, researchers inquired how aerobic exercise could impact hemodialysis-related symptoms among adults with renal failure receiving maintenance hemodialysis. They explored MEDLINE, PubMed, Cochrane CENTRAL, CINAHL, PsycINFO, SPORTDiscus, EMBASE, PEDro, and Scopus databases. Relevant randomized controlled trials were identified. The included studies assessed the impact of aerobic exercise on restless legs syndrome (two studies), sleep disturbance (four studies), anxiety (four studies), depression (nine studies), muscle cramping (one study), and fatigue (one study). According to findings, improvements in various hemodialysis-associated symptoms, including restless legs syndrome, symptoms of depression, muscle cramping, and fatigue, were provided by aerobic exercise in this patient population of adults receiving maintenance hemodialysis. To completely characterize the impact of this intervention, there is need for the use of validated outcome measures with shown dependability as well as responsiveness in more diverse hemodialysis populations.