Brenner H, et al. - In this randomized clinical trial including 2,422 adults (aged 40 to 80 years) not using aspirin (acetylsalicylic acid) or other antithrombotic medications, researchers assessed the potential to increase fecal immunochemical tests sensitivity by administering a single 300-mg oral aspirin dose 2 days before stool sampling. Findings revealed that administration of a single dose of oral aspirin prior to fecal immunochemical testing vs placebo did not significantly increase the test sensitivity for detecting advanced colorectal neoplasms at two predefined cutoffs (10.2 and 17-μg Hb/g stool) of a quantitative fecal immunochemical test among these patients.